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Research Interests

We are best known for our technology development in the area of proteomics - the genome-scale study of changes in proteins. As part of our biomedical engineering effort, we have successfully applied the proteomics approach to develop important new diagnostic tests for prion disease as well as Alzheimer's disease. In partnership with collaborators, we extend the use of our proteomic approach to study relevant molecular changes in response to various treatments that are being developed and are developing techniques to better understand how medicines cross the blood-brain barrier.

We have also used our approach to develop nanoscale devices for the improved separation and analysis of proteins. As chemical engineers, we are interested in ways to improve the manufacturing of biopharmaceuticals via biomolecular & bioprocess engineering as well as to study ways to enhance the secretion of recombinant proteins from E. coli and from CHO cells - the two most commonly used platform technologies for the manufacturing of biopharmaceuticals. Our systems biology efforts rely on proteomic data, as well as studies of gene expression and mathematical frameworks, to help organize data leading to a better understanding of ribosome frameshifting which has the potential to lead to new antimicrobial and antiviral medicines.

An important new area addresses energy & the environment by investigating how to streamline the production of next generation biofuels as well as to study ways to the remediation of pollutants in the environment.

Mass Spectrometry Results:
Protein Identification