2007 - 1996

Publications while at Cornell University:
2007, 2006, 2005, 2004, 2003, 2002,
2001, 2000, 1999, 1998, 1997, 1996


DH Lee, SG Kim, YC Park, SW Nam, KH Lee and JH Seo (2007). Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1.
Journal of Chromatography B. 849:323-330.

EJ Finehout, Z Franck, LH Choe, NR Relkin and KH Lee (2007). Cerebrospinal Fluid Proteomic Biomarkers for Alzheimer's Disease.
Annals Neurology. 61:120-129.

Gupta P, Lee KH (2007). Genomics and Proteomics in Process Development: Opportunities and Challenges.
Trends in Biotechnology 25: 324-330.

R Kuczenski, K Hong, J Garcia-Ojalvo, and KH Lee (2007). Phosphorylated CLK can explain the delay in Drosophila circadian periodicity.
PLoS Computational Biology 3: e154.

Choe LH, D'Ascenzo M, Relkin NR, Pappin D, Ross P, Williamson B, Guertin S, Pribil P, Lee KH (2007). 8-Plex Quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease.
Proteomics 7: 3651-3660.

KH Lee, NR Relkin (2007). "Cerebrospinal fluid biomarkers for Alzheimer's disease". Annals of Neurology.


EJ Finehout, Z Franck, NR Relkin and KH Lee (2006). "Proteomic Analysis of Cerebrospinal Fluid Changes Related to Postmortem Interval". Clinical Chemistry. 52: 1906-1913.

KH Lee (2006). "Editorial". Briefings in Functional Genomics and Proteomics 5: 97.

K Aggarwal, LH Choe and KH Lee (2006). "Shotgun proteomics using the iTRAQ isobaric tags". Briefings in Functional Genomics and Proteomics 5: 112-120.

LH Choe, B Werner, and KH Lee (2006). "Two-dimensional Protein Electrophoresis: From Molecular Pathway Discovery to Biomarker Discovery in Neurological Disorders". NeuroRX 3: 327-335.


R Kuczenski, K Aggarwal, and KH Lee (2005). "Improved Understanding of Gene Expression Regulation Using Systems Biology". Expert Review in Proteomics 2: 915-924.

M D'Ascenzo, NR Relkin, and KH Lee (2005). "Alzheimer's Disease Cerebrospinal Fluid Biomarker Discovery: A Proteomics Approach". Current Opinion in Molecular Therapeutics 7: 557-564.

J Diao, D Ren, JR Engstrom, and KH Lee (2005). "A Surface Modification Strategy on Silicon Nitride for Developing Biosensors". Analytical Biochemistry 343: 322-328.

Y Yang, C Li, KH Lee, and HG Craighead (2005). "A Polymeric Microchip with Integrated Tips and in situ Polymerized Monolith for Electrospray Mass Spectrometry". Lab on a Chip 5: 869-876.

Y Yang, C Li, KH Lee, and HG Craighead (2005). "Coupling On-Chip Solid Phase Extraction to Electrospray Mass Spectrometry Through an Integrated Electrospray Tip". Electrophoresis 26.

LH Choe, K Aggarwal, Z Franck and KH Lee (2005). "A Comparison of the Consistency of Proteome Quantitation Using Two-Dimensional Electrophoresis and Shotgun Isobaric Tagging in Escherichia coli Cells". Electrophoresis. 26: 2437-2449.

EJ Finehout, Z Franck and KH Lee (2005). "Complement Protein Isoforms in CSF as Possible Biomarkers for Neurodegenerative Disease". Disease Markers. 21: 93-101.

E Finehout, J Cantor and KH Lee (2005). "Kinetic Characterization of Sequencing Grade Modified Trypsin". Proteomics. 5: 2319-2321.

C Li, Y Yang, HG Craighead and KH Lee (2005). "Isoelectric Focusing in Cyclic Olefin Copolymer Microfluidic Channels Coated by Polyacrylamide Using a UV Photografting Method". Electrophoresis. 26: 1800-1806.

K Aggarwal, LH Choe and KH Lee (2005). "Quantitative Analysis of Protein Expression Using Amine-Specific Isobaric Tags in Escherichia coli Cells Expressing rhsA Elements". Proteomics. 5: 2297-2308.

EJ Hayduk and KH Lee (2005). "Cytochalasin D Improves Heterologous Protein Productivity in Adherent Chinese hamster ovary cells". Biotechnology and Bioengineering. 90: 354-364.

PS Lee and KH Lee (2005). "Engineering HlyA Hypersecretion in Escherichia coli Based on Proteomic and Microarray Analyses". Biotechnology and Bioengineering 89: 195-205.


KS Brown, CC Hill, GA Calero, C Myers, KH Lee, JP Sethna and RA Cerione (2004). "The Statistical Mechanics of Sloppy Models: Nerve Growth Factor Signaling". Phys. Biol. 1: 184-195.

YC Park, SG Kim, KH Lee, K Park, and JH Seo, "Fed-batch production of D-ribose from sugar mixtures by transketolase deficient Bacillus subtilis SPK1" Applied Microbiology and Biotechnology 66: 297-302.

C Li and KH Lee, "Microfluidic Device for Affinity Removal of Albumin from Human Cerebrospinal Fluid" Analytical Biochemistry (2004).

LB Shaw, JP Sethna and KH Lee, "Mean field approaches to the totally asymmetric exclusion process with quenched disorder and large particles." Physics Review E. 70: 021901 (2004).

E Hayduk, LH Choe and KH Lee, "A Two-dimensional Electrophoresis Map of Chinese Hamster Ovary Cell Proteins Based on Fluorescence Staining" Electrophoresis. 25: 2545-2556 (2004).

EJ Finehout, Z Franck, and KH Lee, "Towards two-dimensional electrophoresis mapping of the cerebrospinal fluid proteome from a single individual" Electrophoresis. 25: 2564-2575 (2004).

EJ Finehout and KH Lee, "An Introduction to Mass Spectrometry Applications in Biological Research". Biochemistry and Molecular Biology Education. 32: 93-100 (2004).

KH Lee and KF Reardon, "Proteomics: An Exciting New Science, but Where are the Chemical Engineers?" AIChE Journal. 49: 2682-2686 (2003).

LB Shaw, A Kolomeisky and KH Lee, "Local Inhomogeneity in Asymmetric Simple Exclusion Processes with Extended Objects". Journal of Physics A Mathematical and General 37: 2105-2113 (2004).

WC Lee and KH Lee, "Applications of Affinity Chromatography in Proteomics". Analytical Biochemistry. 3241-10 (2004).


A Mehra, KH Lee and V Hatzimanikatis, "Insights into the Relation Between mRNA and Protein Expression Patterns. I. Theoretical Considerations". Biotechnology and Bioengineering. 84: 822-833 (2003).

PS Lee, LB Shaw, LH Choe, A Mehra, V Hatzimanikatis and KH Lee, "Insights into the Relation Between mRNA and Protein Expression Patterns. II. Experimental Observations in Escherichia coli". Biotechnology and Bioengineering. 84: 834-841 (2003).

PS Lee and KH Lee, "Escherichia coli-a Model System That Benefits From and Contributes to the Evolution of Proteomics". Biotechnology and Bioengineering. 84: 801-814 (2003).

EJ Finehout and KH Lee, "A Comparison of Automated In-Gel Digest Methods for Femtomole Level Samples". Electrophoresis. 24: 3508-3516 (2003).

LH Choe and KH Lee, "A Quantitative and Qualitative Measure of Intralaboratory Two-dimensional Gel Reproducibility and the Effects of Sample Preparation, Sample Load, and Image Analysis". Electrophoresis. 24: 3500-3507 (2003).

K Aggarwal and KH Lee, "Functional Genomics and Proteomics as a Foundation for Systems Biology". Briefings in Functional Genomics and Proteomics, 2: 175-184 (2003).

LB Shaw, R Zia and KH Lee, "Modeling, Simulations and Analyses of Protein Synthesis: a Driven Lattice Gas with Extended Objects". Physical Review E 68: 021910 (2003).

C Li, WC Lee, and KH Lee, "Affinity Separations Using Microfabricated Microfluidic Devices: in situ Photopolymerization and Use in Protein Separations". Biotechnology and Bioprocess Engineering. 8: 240-245 (2003).

E Hayduk, LH Choe and KH Lee, "Proteomics as a Tool in Discovery-Based Science". Current Science 83: 840-844 (2003).


Choe, L.H., Dutt, M.J., Relkin, N. and K.H. Lee, "Studies of Potential Cerebrospinal Fluid Molecular Markers for Alzheimer's Disease". Electrophoresis 23: 2247-2251 (2002).

Choe, L.H., Green, A., Knight, R.S.G., Thompson, E.J. and K.H. Lee, "Apolipoprotein E and Other Cerebrospinal Fluid Proteins Differentiate Antemortem Variant Creutzfeldt-Jakob Disease from Antemortem Sporadic Creutzfeldt-Jakob Disease". Electrophoresis 23: 2242-2246 (2002).

Reardon, K.F., K.H. Lee, Wittrup, K.D. and V. Hatzimanikatis "Jay Bailey as Mentor - The Students' Perspective". Biotechnology and Bioengineering 79: 484-489 (2002).


Dutt, M.J. and K.H. Lee, "The Scaled Volume as an Image Analysis Variable for Detecting Changes in Protein Expression Levels by Silver Stain". Electrophoresis 22: 1627-1632 (2001).

K.H. Lee, "Proteomics: A Technology-Driven and a Technology-Limited Discovery Science". Trends in Biotechnology 19: 217-222 (2001).
Reprinted from trends in Biotechnology with permission from Elsevier Science. Single copies of this article can be downloaded and printed for personal research and study purposes only.

Chen, W., F. Bruhlmann, K.H. Lee, M. Deschusses, "Whole Cell Catalysis". In Encyclopedia of Catalysis, I Horvath, ed. New York: Wiley (2001).


Hatzimanikatis, V., Collins, D., Lawrence, S., Browning, S. and K.H. Lee,"Bioinformatics, Genomics and the Chemical Engineer - a Perspective". Chemical Engineering Education 34: 346-349 (2000).

Dutt, M.J. and K.H. Lee, "Proteomic Analysis". Current Opinion in Biotechnology, 11: 176-179 (2000).

Lee, P.S. and K.H. Lee, "Genomic Analysis". Current Opinion in Biotechnology, 11: 171-175 (2000).

Choe, L.H. and K.H. Lee, "A Comparison of Three Commercially Available Isoelectric Focusing Units for Proteome Analysis: the Multiphor,the IPGphor and the Protean IEF Cell". Electrophoresis, 21: 993-1000 (2000).


Hatzimanikatis, V., K.H. Lee, J.E. Bailey, "A Mathematical Description of Regulation of the G1-S Transition of the Mammalian Cell Cycle". Biotechnology and Bioengineering, 65: 631-637 (1999).

Choe, L.H., W. Chen, K.H. Lee, "Proteome Analysis of Fis Overexpression in E. coli". Electrophoresis, 20: 798-805 (1999).

Hatzimanikatis, V., L.H. Choe, K.H. Lee, "Proteomics: Theoretical and Experimental Considerations". Biotechnology Progress, 15:312-318 (1999).

Hatzimanikatis, V., K.H. Lee, "Dynamical Analysis of Gene Networks Requires Both mRNA and Protein Expression Information". Metabolic Engineering, 1: 275-281 (E1-E7) (1999).


Lee, K.H. and M.G. Harrington, "Double-Label Analysis". In 2-D Proteome Analysis Protocols, A Link, ed. New York: Humana Press, Pages 291-295 (1998).

Lee, K.H. and M.G. Harrington, "Preparative Gel Electrophoresis". In Gel Electrophoresis of Proteins, BD Hames, ed. Oxford: Oxford University Press, Pages 93-104 (1998).


Lee, K.H. and M.G. Harrington, "The Assay Development of a Molecular Marker for Transmissible Spongiform Encephalopathies". Electrophoresis 18: 502-506 (1997).

Lee, K.H. and M.G. Harrington, "14-3-3 and BSE". Vet. Record. 140: 206-207 (1997).


Lee, K.H., A. Sburlati, W. Renner, J.E. Bailey, "Deregulated Expression of Cloned Transcription Factor E2F-1 in Chinese Hamster Ovary Cells Shifts Protein Patterns and Activates Growth in Protein-Free Medium". Biotech. Bioeng., 50: 273-279 (1996).

Lee, K.H., M.G. Harrington, and J.E. Bailey, "Two-Dimensional Electrophoresis of Proteins as a Tool in the Metabolic Engineering of Cell Cycle Regulation". Biotech. Bioeng. 50: 336-340 (1996).

Lee, K.H. and M.G. Harrington, "Premortem Diagnosis of Creutzfeldt-Jakob Disease by Cerebrospinal Fluid Analysis". The Lancet, 348: 887 (1996).

Will, R.G., Zeidler, M., Brown, P., Harrington, M.G., Lee, K.H. and Kenney, K., "Cerebrospinal fluid test for new variant Creutzfeldt-Jakob disease". The Lancet, 348: 955 (1996).

Hsich, G., Kenney, K., Gibbs, C.J., Lee, K.H. and Harrington, "The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies". The New England Journal of Medicine, 335: 924-930 (1996).

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